Efficient vaccination depends on correct administration and administration. Vaccines could be administered by way of consuming water, spray, eye-drop, injection, or in-ovo (that means that the vaccine is injected within the egg).

• Recombinant vaccines could be administered in-ovo which is achieved by injecting the air cell of fertile eggs (concentrating on amniotic sac or intramuscular/subcutaneous administration) between 18 or 19 days of incubation utilizing a machine on the hatchery or could be injected at day of age.
• Modified-live vaccines could be utilized on the hatchery by way of in-ovo, spray, or injection or on the farm by way of consuming water, spray, eye-drop, or injection. Inactivated vaccines are generally utilized in broiler breeders since such a vaccine requires particular person administration by way of injection.
• Vaccines could be injected by way of cutaneous (wing-web), sub-cutaneous (inguinal fold, neck), or intramuscular (breast, leg) routes.

Poultry veterinarians attempt to match the the place the vaccine is run to how chickens could be naturally uncovered to that particular pathogen. For instance, consuming water administration is used for modified-live vaccines, equivalent to infectious bursal illness, because the goal organ of this illness is the intestine.