Inexperienced-lipped mussel & osteoarthritis remedy: How considered one of nature’s strongest anti-inflammatories works

Are you involved about your canine’s mobility and joint well being? Dive into this weblog to get a greater understanding of the well being advantages of green-lipped mussel for canines and the way it will help relieve the signs of osteoarthritis and scale back using anti-inflammatory medicine.

Mobility is the important thing factor in conserving our canine pals wholesome and pleased for a few years to come back. Considering again to my first canine, Skai, I used to be so grateful he was in a position to go mountaineering with us within the mountains even on the age of 15.

However whereas he appeared unstoppable, ultimately stiffness and aches began to set in. Seeing your canine decelerate is hard for any pet mother or father as mobility is every thing for them — it is pleasure, freedom, and life itself.

Fortuitously, there are pure methods to help your canine’s mobility and enhance their lifespan, considered one of them being the Perna mussel or green-lipped mussel.

In 2009, a research referred to as An evidence-based systematic evaluation of green-lipped mussel (Perna canaliculus)(1) confirmed that New Zealand green-lipped mussel gives a clinically important constructive remedy impact on osteoarthritis (joint irritation). 

This research included a evaluation of 9 medical trials, specializing in the consequences of green-lipped mussels on OA ache and mobility, however additionally confirmed that green-lipped mussels improved gastrointestinal signs in OA sufferers taking non-steroidal anti-inflammatory medicines (NSAIDs) which are broadly utilized in human and veterinary drugs. These medicine are identified to trigger gastrointestinal, kidney, and liver unwanted effects, leading to a deeper imbalance within the physique.

However that is not all, what makes green-lipped mussels so useful for canines and other people lies within the highly effective vitamins it accommodates. 

What makes green-lipped mussels so distinctive?

A current research carried out by a Japanese analysis crew centered on the compounds behind the green-lipped mussel’s constructive results on joint well being, ache administration, and mobility — the bioactive glycosaminoglycans (GAGs)(2).

Marine invertebrates comparable to mussels are a wealthy supply of those extremely sulfated and uncommon glycosaminoglycans. Perna canaliculus is without doubt one of the finest sources produced on a big scale in New Zealand. 

The glycosaminoglycans from the green-lipped mussel, primarily chondroitin sulfate (CS) and heparan sulfate (HS), exhibit a number of notable organic results:

1. Encouraging nerve progress: Sure chondroitin sulfate chains, particularly these with a selected sort of sugar pairing (GlcA-GalNAc(4,6-O-disulfate)), have been discovered to assist in the creation of connections between nerve cells. This discovery hints at potential makes use of within the fields of neurology and regenerative drugs, the place selling nerve progress and restore is required.

2. Joint well being and osteoarthritis remedy: Chondroitin sulfate is often used for its potential advantages in joint well being, notably within the remedy of osteoarthritis. It’s believed to contribute to the upkeep and restore of cartilage, the connective tissue that traces and cushions joints.

3. Anti-inflammatory properties: Each chondroitin sulfate and heparan sulfate possess anti-inflammatory properties, that are useful in decreasing irritation in circumstances of arthritis.

4. Tissue homeostasis (stability) and cell proliferation (creation and progress): GAGs play crucial roles in mobile phenomena like cell proliferation, cell adhesion, differentiation, and tissue homeostasis.

One other research, this time analysing the consequences of a food plan enriched with green-lipped mussel in canines with osteoarthritis(3),  noticed that there was a big enhance in Omega-3 fatty acids ranges of their blood after 60 days. The homeowners additionally reported enhancements of their canines’ ache and exercise ranges after switching to this food plan. 

Why I selected so as to add green-lipped mussel to JointButter

For these of you who’ve missed the most recent information, JointButter, our new product and the world’s first fermented joint and mobility help complement for canines, will likely be quickly added to our product line up.  

I’ve researched numerous vitamins, herbs, and superfoods for a few years so as to give you the very best formulation that will make a transparent distinction for our canines’ joint well being and mobility.

That is how I got here throughout the green-lipped mussel and its highly effective anti-inflammatory and joint-repair properties. The glycosaminoglycans (GAGs) from Perna mussels have a novel construction and bioactivity, making it a preferred ingredient in canine and human mobility formulation.

Whereas I’ve additionally added chondroitin sulfate and glucosamine to JointButter, the addition of a whole-food supply of GAGs from Perna mussels considerably boosts the efficiency of the complement and will increase the spectrum of accessible glycosaminoglycans. 

How are green-lipped mussels raised and harvested? 

Produced solely in New Zealand, green-lipped mussel manufacturing includes a number of steps.

Seeds are first collected and planted in a hatchery. As soon as they hatch into larvae, they connect themselves to rocks, lengthy ropes, and different onerous surfaces.

As soon as connected, a metamorphosis into juvenile and consecutively into grownup mussels follows. Inexperienced-lipped mussels are able to be harvested in 26 to 48 months.

A be aware on the sustainability of green-lipped mussel manufacturing

When formulating JointButter, my crew and I didn’t simply deal with the standard and science-backed efficacy of the elements we chosen; we additionally paid shut consideration to their environmental sustainability. 

The areas the place Perna mussels are harvested are underneath the stewardship of the producers in a profitable collaboration with Mussel Reef Restoration Belief and Revive Our Gulf Basis.

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Article references:

1. ”Inexperienced-lipped mussel evaluation” by Catherine Ulbricht and crew. PMID: 22435354 DOI: 10.1080/19390210802690191